GRAM spoke with Josh Crossney, the founder of Cannabis Science Conference, one of the leading cannabis conferences in the U.S. brings together medical, analytical science, and cultivation experts. More on that in a minute.
A career in staffing and recruiting for some of the biggest biological labs across the U.S. gave Josh an in-depth understanding of the importance of quality control and testing. That is what drove him into the medical cannabis industry in 2014. “It really was kind of alarming to me that at the time there were no requirements or quality control testing for cannabis.”
“I connected with some people who were using cannabis as medicine out in California and a couple people who were treating children with cannabis,” he says. “Everything, just about, that comes in contact with humans—from food to beauty products to even water and wastewater—has quality control standards or testing,” he says.
A passion for changing that was one of the things that drew Josh into the industry. Educating people about medical cannabis was another. “I realized there wasn’t a lot—really any—platforms at the time, that were really catering and creating a space for the world’s leading researchers and medical professionals and cultivation experts to come together and share their information with other like-minded people,” he says. In October 2016, Josh launched the first Cannabis Science Convention in Portland, Oregon.
It really was kind of alarming to me that at the time there were no requirements or quality control testing for cannabis.
That first show drew about 800 attendees and 75 vendors. By 2019 the event was pulling in close to 3,500 people and almost 200 vendors. Last year, he launched the inaugural Cannabis Science Convention East at the Baltimore Convention Center in Maryland.
“It really was a full circle moment for me when we were able to say ‘Hey, it’s been a few years. The East Coast has really developed when you look at states like Maryland, New Jersey, Pennsylvania, Delaware, and New York that have implemented medical cannabis programs since the time we launched the (Oregon) show.’” The move paid off, attracting over 2,000 attendees and about 110 vendors.
Josh is a voice in the cannabis industry for the LGBTQ community, and he regularly speaks about the importance of diversity and inclusion. “More so than most industries that I’ve been a part of, the cannabis industry, and the folks and the colleagues I’ve worked with are very accepting and open to all types of people,” Josh says.
He states that the cannabis community and LGBTQ community might have more in common than you would think. “A lot of people don’t realize how many intersections there are between the LGBTQ community and the struggle that we went through in the U.S. and globally, also with the cannabis community. These are both two communities that have been unfairly marginalized and stigmatized by society.”
Josh said that both are human rights issues that have gained traction on a state-by-state basis. He also pointed out that when California implemented medical cannabis in 1996, it was “largely due to the advocacy, leaders, and pioneers who were pushing for this as an option for the HIV and AIDS communities.”
“There are a lot of crossovers that people don’t realize. Cannabis has been used and accepted as a medicine in society for far, far longer than it has been stigmatized as one.”
A serious car accident in the winter of 2009 triggered Josh’s firsthand experience using cannabis as medicine. Returning home during a snowstorm from a sleigh-riding excursion, the car he was riding in crashed into the back of a state snowplow.
More than a decade later, he still suffers from back and shoulder pain as a result. “I use cannabis as an alternative to the opiates that everyone gets prescribed when you have injuries like that,” he said. It also helps him with PTSD from the accident. “As a passenger, it was very intense. For me, it can be challenging to be a passenger in cars at times. Cannabis really does help me deal with that.”
Josh also finds relief for his anxiety. “There’s not a lot of pharmaceutical options other than benzos, which really are just as bad as opiates; they really turn you into a shell of yourself. So I just found that cannabis, for me, was a much better, safer alternative that actually worked a lot better than prescription drugs.”
Knowing firsthand the benefits, Josh has big goals “to educate the masses and let people know this is an option.” He has his own Maryland-based 501(c)3 non-profit called jCanna—focused on advancing cannabis science and specifically cannabis quality control testing and extraction processes and standards. “Everything that I do, everything that I touch in this industry really is, at the core, trying to drive more normalization of this plant, acceptance of this plant.”
“We’re having to dig out of 50 plus years of misinformation and propaganda. It’s not a new conversation. Prohibition and reefer madness was really something that was based on racism and greed and the need and want to monopolize the American industry, like pharmaceutical and paper. A lot of people don’t realize the first draft of the Constitution was drawn up on hemp paper.”
However, Josh doesn’t see cannabis advocacy as a blanket label and acknowledges people disagree. “I’m definitely all for adult use and recreational use, and this being legalized and normalized federally,” he said. “But I also am a major proponent of medical, and I would hate to see the government say, ‘Well, we’re gonna go ahead and legalize this for recreational use, but we’re not gonna call this a medicine.’
“If that was the case and this was regulated like alcohol, how would the 10-month-old babies, the 2-year-old children, the people who are using this as a medicine, how would they have access to this if it was regulated like alcohol, and it was a 21-or-over situation without any option for them? Yes, legalizing and normalizing this plant federally but also maintaining the medical term, and that this is a medicine.”
We really feel that knowledge is power and empowered patients can make the best decisions about their cannabis care.
As a board member of the California based CannaKids, Josh cares deeply about pediatric cannabis use. “If this is legal in your state for an adult to use a medical condition, I think that it should not be any more stigmatized for a pediatric patient going through the same condition to have this as an option.”
This brings him back to the importance of quality control and testing in the cannabis industry. “If you’re treating a sick pediatric cancer patient who’s going through chemo and radiation with a highly compromised immune system, contaminated cannabis with mold, heavy metals, or solvents can really negatively affect their health.” It’s not just about contamination, but knowing exactly what is in the medicine and how strong it is. “That is important when you are talking about trying to target and treat conditions. We just want this natural plant to be as natural as possible” he says.
In fact, Josh has a quality control dream. “I would love to see this standardized and have quality control required and standardized all over the country and get it to a point where you can send a cannabis sample to five different labs and get the same result. The problem right now is if you sent a cannabis sample to five different labs, there’s not standardization. They’re using different types of instrumentation, different processes. Any of these factors can change the results of your certificate of quality.”
Josh is constantly busy travelling, speaking, and expanding the Cannabis Science Convention.
“We’re continuing to grow the shows. We’re on the East Coast and the West Coast. We have been dabbling with the idea of a Midwest show at some point. We’re also really strongly looking at international markets. We’d love to, potentially, do a show in Germany where cannabis is just starting to develop.”
“This year, one of the new things is in addition to our analytical science, medical cannabis, and cultivations tracks, we’ve also launched a whole 2-day hemp/CBD track.”
Adding the hemp/CBD track is just one way Josh is continuing to educate medical professionals and patients. He is also involving the academic community by shining a light on their contributions to the cannabis science through developments in the curriculum at Johns Hopkins, Rutgers, and Northern Michigan University, and the University of Maryland School of Pharmacy.
“We really feel that knowledge is power and empowered patients can make the best decisions about their cannabis care.”
Keeping Love + Faith Alive
After losing 36 to Covid-19
What started as a “Shelter in Place” check-in with friends Barbara and Daniel Melvin, grew into this article about a family with extreme losses to COVID-19. Barb first told me they had lost 12 family members and friends from COVID-19 in mid-April. By the end of April, the number had grown to 33. The current count is 40 family and friends lost to COVID-19 as of May 18, 2020.
Daniel and Barbara lived in Detroit before relocating to Naples, Florida, in 2001. Barbara has worked in banking for 30 years and is currently a Vice President at First Florida Integrity Bank. Dan is a multi-talented singer, radio personality, and entrepreneur. They are two of the happiest, kindest, giving, and loving people you could be lucky enough to know.
Together, they have worked to give back to their community through philanthropic endeavors, as well as volunteering on numerous nonprofit boards. They celebrate their mutual birthdays, Sept 6 & 10 by holding an annual event called “Party Hearty for Charity,” formerly known as “Party with a Purpose,” their nonprofit organization., They have raised over $90K in the past six years to help support several nonprofit organizations in SouthWest FL.
Barb says, “The coronavirus is real. I first heard about it in March, but like everyone else, we didn’t understand it, and at that time, we didn’t personally know anyone that was sick from it. Then, as time went on, we started to hear about people that we knew who were dying. My husband and I hated to wake up and look at Facebook because it seemed every time we checked someone close to us or someone we knew had died.”
Barbara tells us, some of the churches in Detroit continued to hold services, after the recommendation not to gather in large numbers. The members met to seek comfort in the face of the pandemic. Barbara believes that was crucial for most of the people she knows who were infected and died.
How could one couple know so many people who have passed from COVID-19? They are an extensive close-knit family, descendants of Tom and Etta Rhoades, born slaves. Tom and Etta’s dreams were to keep their descendants together spiritually, in harmony, and in brotherly love. They have honored their ancestors by gathering each year, for 46 years, for a three-day family reunion. Friday is meet and greet (you would need it with over 200 attending). Saturday is picnic time, complete with a softball game between the North and the South. Sunday, everyone goes to a local church, followed by a family dinner. With all those family members together, not an argument or fight ever. Until 2020, when the pandemic hit the family, and they canceled the family reunion.
Barbara shares with us information on a few of those they have lost. “My aunt, Mary Rhoades, died on April 22, 2020, she was 97 years old. She was in good health, and we were praying she made it to 100.” Several of her siblings had achieved that milestone, and she was reasonably healthy for 97 years of age so that expectation was a real one. “Aunt Mary became infected in early April; two weeks later, she was gone. She went to the hospital in Philadelphia for minor surgery, and we believe she was infected there. What hurts the most is she died alone; no family or friends could visit her.”
“Jason Hargrove was a close friend of ours. He was the bus driver who went on Facebook Live to talk about a woman coughing on his bus without covering her mouth. Two weeks later, he was diagnosed with the coronavirus, and he died shortly thereafter. His death was not in vain as the Detroit Department of Transportation made many changes to enhance the safety of their drivers. Jason was a Deacon at my church.”
Barbara continues, “Another close friend of ours was Larry Griffin. He died on April 16. He sang in my husband’s band called “In Full Effect” when they were performing in Detroit. He continued to sing in a new band called “Serieux,” who performed mostly in Detroit but also in Las Vegas. He had a beautiful voice and some great dance moves. He was so healthy until he caught the virus, and, in weeks, he was gone.”
“It spread so much faster in the churches. Many Pastors we knew caught the virus and were gone. They were older and many had health issues, when the virus attacked them they could not fight it off. These 4 Pastors were all a part of the Church of God In Christ (COGIC). Many had large congregations and were still holding services after the call for social distancing. These great men are a true loss for the COGIC community.”
“On April 23, we lost a very dear friend of mine, Lynn Raimey. I called her my sister as her father was the Pastor of my church in Detroit. Her family took me in and treated me like family when I first moved to Detroit and didn’t know anyone. She had many health issues, so when she was infected by the virus, it killed her very quickly.”
“Although we have lost many family, friends, and associates, we know God is good, and he continues to show us favor even through the midst of this storm. Even though we know of many deaths, we also know of many survivors and to that we are grateful. These people are given a second chance so their test can become their testimony. I know of an entire household, The Washington family of Detroit, who are survivors. Pastor Jamonty, his wife Tamela and their daughter Ariel Washington all recovered and are doing well.”
Barb specifically finds strength in the Beatitudes; “Jesus said in Matthew 5:4, Blessed are they that mourn, for they shall be comforted. It is during these tough times of losing loveda ones that I can refer to scripture to give me the comfort I and my family needs. The question is have you ever suffered? Please know that we all have. But I have come to know through leaning on God and his word, he meets me at my very point of need. As believers, the Bible speaks about plagues and famine and death, and its teachings prepare us for what life has to offer. Oftentimes we don’t understand the current situations, but when we look back, we realize this had to happen.”
As of May 5, 2020, there have been over 72,000 deaths in the United States, and over 257,000 deaths Worldwide. It is critical to find strength either within or in a higher power, focus on the positive, and stay connected.
It is GRAM’s honor to recognize this incredible family.
Blessed are they that mourn, for they shall be comforted.
Family & Friends Lost to Covid-19 (35 as of 5/5/20)
Mary R. – PA
Jason H. – MI
Rachelle Lynn R. – MI
Rev. O’Neil S. – MI
Gerald H. – MI
Curtis H. – MI
Larry G. – MI
Rosalind C. – MI
Rev. Gerald G. – VA
Skylar H. – MI
Rev. David F. – MI
Laneeka B. – MI
Ejuan W. – MI
Darnielita B. – MI
Bishop Phillip B. – MI
Bishop Robert S. – MI
Bishop Robert H. – MI
Tatia W. – MI
Rev. Lonie J. – MI
Carrie W. – MI
Helena J. – VA
James J. – VA
Robert J. – VA
Annette W. – NY
Helen L. – MD
Walter H. – DC
Carol T. – DE
Benjamin T. – DC
William B. – KY
Daniel R. – TX
Karen S. – NC
Denise B. – NC
Doris M. – OH
Trina D. – MI
Earl T. – VA
Nathaniel S. – MI
Lonnie L. – MI
Nathaniel S. Sr. – MI
Nathaniel S. Jr. – MI
Angel R. – IL
Americans for Safe Access + Covid
Americans for Safe Access (ASA) is a 501(c)(3) nonprofit with the mission of ensuring safe and legal access to cannabis for therapeutic use and research. The organization began in 2002 and has been helping educate people, change laws, and get more research out there about the therapeutic benefits of medical cannabis. “We also care about safety, and we want to make sure patients are using cannabis safely and legally throughout the United States,” explains Debbie Churgai, Interim Director for ASA.
GRAM sat down with Churgai to discuss how they are handling COVID-19 for patients throughout the U.S. She tells us, “When it first started, patients were really concerned about there being a lack of access to their medicine. So, one of the first things we did was host a stakeholders call. We contacted a bunch of people: patients, industry professionals, medical professionals, legal professionals, and within two hours, 15-20 people were on the phone strategizing. From that phone call, we then created a letter that we sent to Governors, medical cannabis commissions, and health departments urging them to keep medical cannabis businesses as essential, not just the dispensary but also cultivation and manufacturers so that there was no stop in production or supply chain.”
“It also meant, we needed to make sure patients were receiving safe products, that employees were also being kept safe. Then we started thinking about delivery for states that did not have that yet, and the states that did not yet offer telehealth – we wanted to encourage the changing of regulations at least temporarily to help accommodate the patients. As well as things like tax relief and adding additional caregivers, it wasn’t just about keeping businesses open, it was about making sure that patients were being protected and that products and employees were safe.”
In Colorado, we have seen dispensaries adapt to this crisis by adding hand sanitizer at checkout counters, wearing gloves and masks and only allowing one person in the purchasing area at a time. 33 states now have some sort of medical cannabis program.
According to news around the U.S., cannabis is now considered essential. But it wasn’t that way at first. According to Churgai, “Some states seemed to hold back on making any temporary changes in regulations. Within two weeks though, all the other states began implementing the suggestions we recommended.”
We needed to make sure patients were receiving safe products, that employees were also being kept safe.
“California has reached out more than any other state, I believe that is due to the fact that every single county there is different, from its tax structure to its implementation of the laws. Massachusetts was high with the questions as well because of them deciding to close down their recreational dispensaries for adult use. Now there is an influx of new patients. Now there are new concerns.”
Each state has a different set of rules and regulations surrounding their medical cannabis programs. “We wanted businesses to all have the same information so we offered a live training on health and safety during COVID-19, that can now be purchased as part of our Patient Focused Certification.1 In the training we provide information such as how to properly put on and take off gloves, how to properly touch things, how to properly sanitize surfaces, and more to make sure that businesses are being as safe as possible during this time.”
“When we realized that we helped assist in making these services essential, we wanted to learn how they actually worked for patients throughout the U.S. We wanted to understand, what do they still need during this time? Are their needs being met as patients? Would they like to see services like telehealth and delivery continue after COVID-19? We realize that we really need to streamline our advocacy efforts at this time, and we felt the survey would be a great way to learn what we can do for patients out there,” Churgai explains.
Help ASA discover what patients need around the United States.
Take the survey here: https://www.safeaccessnow.org/covid-19_survey
COVID-19 Patient Experience Survey asks questions like:
• How do you obtain cannabis?
• Do you feel you are at risk for covid and why?
• Rate your state’s response to the covid crisis.
• How should your state be assisting you more?
Patients are at greater risk for a variety of reasons so ASA is working to ensure that the needs of patients are taken into account. So, in addition to creating this survey, Americans for Safe Access has also created a page on their website dedicated to resources for patients seeking information surrounding COVID-19.2
Churgai says, “Cannabis is real medicine. I have been in this industry for so long, and I am a realist, and I know things will not change overnight. But I do feel the pandemic has highlighted the need for this medicine to be seen as real medicine. At ASA, patients are our priority, we are unbiased, we are not paid to play, and patients will always be our top priority.” You can learn all about Americans for Safe Access by visiting their website: https://www.safeaccessnow.org/
Trends in Endocrinology + Metabolism
The quest for a healthy
Endo-Cannabinoid System (ECS)
Emphasis on immunoregulation
The ECS is a disperse system, extending throughout the body; it is in constant interplay with all other organ systems promoting homeostasis in almost every aspect. Despite that, the ECS is still neglected and not included in the curricula of medical schools. For this reason a few introductory notes are in order (Battista et al, 2012). The ECS is the regulator of cognition, mood, nociception, energy metabolism, oxidation, inflammatory processes and a disease modifier as well (Tantimonaco et al, 2014).
The ECS consists of receptors, ligands to these receptors and enzymes that synthesize and degrade these ligands. The number of known endocannabinoid receptors is still growing to more that 55; the two most outstanding receptors are CB1R, mainly distributed throughout the nervous system and responsible for the psychoactivity of cannabis, and CB2R, mainly distributed on immune cells, even those “disguised” as specialized cells within other organs. Other receptors include TRPVx, GPR55, PPaRs etc; all these receptors form dimers between them as well as heterodimers with other types of receptors, like opioid, dopamine, serotonin, adenosine, catecholamine receptors and many others, thereby promoting a universal regulatory interplay throughout the body. The ligands to these receptors are the endocannabinoids (ECs): lipids of the eicosanoid family, derivatives of arachidonic acid (AA); the latter abounds in cell membranes; five of these are well characterized to date, but two are well studied: Anandamide (AEA) and 2-Arachidonoyl-Glycerole (2AG). ECs in the nervous system act in negative feedback loops, more or less like neurotransmitters, but, unlike them, they are synthesized and degraded on demand, and not stored in micro-vesicles. Several formerly unrelated morbid conditions are now recognized as ECS deficiencies, including, among many, migraine, autism, fibromyalgia, irritable bowel syndrome, etc (Russo, 2016).
The endocannabinoid system is involved in immunoregulation through the CB2 receptor and through receptor independent biochemical pathways. The mechanisms of immunoregulation by ECs include modulation of immune response in different cell types, effect on cytokine network and induction of immunoapoptosis; in brief, ECs down-regulate the innate and adaptive immune response in most, but not all, instances. Manipulation of endocannabinoids in vivo may constitute a novel treatment modality against inflammatory disorders.
It is obvious that the health of the ECS is of great importance in many ways, including the facing of a viral infection like COVID-19. A healthy ECS depends on many factors, most importantly from proper nutrition (McPartland et al, 2014).
Dietary ω3 fatty acids seem to act as homeostatic regulators of the ECS, acting in opposite directions if consumed by obese or non-obese individuals. Little change in EC levels are seen in individuals with normal weight, not fed a high ω6 diet.
Dietary ω6 fatty acids are also essential, but should be in a balance to ω3s; suggested balance is ω3:ω6=1:1 to 1:3 for proper ECS signaling and prevention of peroxidation in general. Arachidonic acid is an essential component of the ω6 fatty acids.
Probiotics and prebiotics play a significant part in ECS health, but, for a bizarre reason, they are generally not mentioned: They up-regulate CB2Rs residing on immune cells of the gut; they also modulate CB1Rs, depending on conditions, for instance, they down-regulate CB1Rs in obese individuals and help them gain less or no fat.
Some flavonoids, like kaempferol, genistein, epigallocatechine gallate, and curcumin enhance the ECS; same happens with some anthocyanidins, like cyanidin and delphinidin, although with a different mechanism.
Phthalates, pesticides, additives to pesticides like piperonyl butoxide act as ECS disruptors, meaning that consuming organic food may be a sound protective measure, along with intake of detoxifiers, in case of health problems consistent with ECS deficiency not otherwise explained.
Chronic stress impairs the ECS by decreasing levels of AEA and 2AG, and possibly through changes in CB1R expression too. Stress management may reverse the effects of chronic stress on ECS signaling. Anecdotal reports and common experience suggest that techniques such as meditation, yoga, deep breathing exercises and practicing of sex as well, exhibit mild cannabimimetic effects, thereby balancing the system.
Exercise is also an ECS regulator: Long-term exercise leads to sustained elevations of ECs, and predictable CB1R down-regulation.
Chronic alcohol consumption and binge drinking likely desensitize or down-regulate CB1R and impair EC signaling. Alcohol is not compatible with a healthy ECS.
Nicotine is an ECS deregulator: It induces EC production in some areas of the brain, while decreasing them in others. It should be avoided too.
Caffeine, acutely administered, potentiates CB1R-mediated effects through antagonizing adenosine at the A1 receptor (AA1R). At the undisturbed state, AA1Rs tonically inhibit CB1R activity; Caffeine antagonism on AA1Rs sets CB1Rs free of inhibition, thereby enhancing ECS function, for example by letting 2AG activate CB1Rs. During chronic administration of caffeine, the effects are blurred by individual differences in adaptation. In general, CB1Rs are down-regulated.
Chocolate: Cocoa contains sm-all amounts of at least three N-acyl-ethanolamines with cannabimimetic activity, expressed either directly by activating cannabinoid receptors, or indirectly, by increasing AEA levels (di Tomaso et al, 1996).
Battista et al, 2012: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303140/
Tantimonacco et al, 2014: https://pubmed.ncbi.nlm.nih.gov/24526057/
(Russo, 2016): https://pubmed.ncbi.nlm.nih.gov/28861491/
(McPartland et al, 2014): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951193/
(di Tomaso et al, 1996): https://pubmed.ncbi.nlm.nih.gov/8751435/
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