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Education & Research

Doctors That Inspire

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Dr. Donald P. Tashkin is Emeritus Professor of Medicine in the Division of Pulmonary and Critical Care Medicine at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). He previously served as Director of the Clinical Pulmonary Function Laboratory at the UCLA Medical Center for approximately 30 years and as interim chief of his division. His research interests include the pathophysiology, prevention and treatment of COPD, the pathophysiology and clinical pharmacology of asthma, the evaluation and treatment of scleroderma-related interstitial lung disease (SSc-ILD), the pulmonary effects of abuse of smoked substances (including marijuana, crack cocaine and tobacco) and of community air pollution. He is a member of the Editorial Boards of Chest, Respiratory Research, Respiratory Medicine and the Journal of the COPD Foundation, Guest Editor for numerous leading scholarly medical journals and Chair of the External Advisory Committee for the American Lung Association Airways Clinical Research Centers. He has also served as a member or Chair of several Data and Safety Monitoring Boards (including several American Lung Association Airways Clinical Research Centers clinical trials).

His preliminary slides for his presentation made us think that his study was going to link marijuana and lung disease, just like the name of his study, Marijuana and Lung Diseases, Published September 2018, Chest Journal.

He began his presentation with facts about how marijuana shares most toxic ingredients with tobacco smoke; however,  the evidence does not support the same respiratory risk as those that smoke tobacco.

By the end of his lecture, we were enlightened that there are things we have been told over the years about smoking marijuana that were not based in science.

On the next pages are highlights from the 32 page study we thought you should know are based in science.

MARIJUANA & LUNG DISEASES

The study done by Dr. Tashkin gives evidence to suggest that there is no correlation between pneumonia and marijuana smokers even in those that are immune compromised or immunosuppressed.

In the SPIROMICS STUDY they found the frequent cannabis users had lower levels of emphysema in the lung on high definition CT-scans then even that of non-cannabis users, never- users, tobacco users and cannabis and tobacco users. 

In long term studies of the pulmonary function of the total lung capacity, the forced vital capacity was compared between habitual marijuana smokers and habitual tobacco smokers. 

Marijuana and lung cancer: There are studies to support both sides of this argument. However, the studies that support evidence promoting the link between lung cancer and smoking cannabis have some major flaws. 

While Tobacco & Marijuana share some of the same toxic ingredients, cannabis has THC & cannabinoids in it that have a counteractive effect to the toxic properties of the smoke. 


STUDY HIGHLIGHTS Dr. Donald P. Tashkin, M.D.

Collected by Sarah Moss

  • Comparitively, studies show that when THC and other cannabinoids are combined, they have a tumor-suppressive effect in both cell culture studies and animal model studies. 
  • A major review of six studies of habitual marijuana smoking found that habitual marijuana smoking did not lead to any significant evidence of an increase in risk of lung cancer.
  • Habitual marijuana smokers had greater lung capacity which didn’t decline like that of tobacco smokers whose lung capacity declined severely over the course of the study. 
  • Frequent use of smokable cannabis does increase the risk of chronic bronchitis and can cause injury to the large airways; however, THC has an immunosuppressive effect on the cannabinoid type-2 receptors. Therefore while the immune cells may not be able to kill bacteria as easily and efficiently, it can lead to long-term protection against other diseases like COPD due to the anti-inflammatory nature of the THC molecule itself. 

READ THE ENTIRE ARTICLE HERE

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Education & Research

What’s Working for Stress Issues

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Releaf is a free mobile app that encourages patients to mindfully track their cannabis experiences. They believe you will strengthen your relationship with yourself while also learning how cannabis can help alleviate your specific issues and ailments. GRAM is proud to share with our readers data gathered using Releaf from individuals suffering from stress symptoms. 

They reported the effectiveness of products for specific symptoms of individuals suffering from anxiety, insomnia, agoraphobia, depression, PTSD, and gastrointestinal problems. The data reflect their individual experiences self-reported using the Releaf App.


Top Rated in USA

Anxiety

  • Orange Cream, Concentrate | The Clear | Colorado
  • Zen Pure Reserve Oil, Concentrate | Surterra | Florida
  • Ac/Dc, Flower | Opc Cultivation | Ohio

Insomnia

  • Grape Dreams, Concentrate | Evolab | Colorad
  • Cherry Chem Og, Concentrate | Ascend Illinois | Illinois
  • 707 Headband Live Resin Budder, Concentrate | Cresco | Pennsylvania

Agoraphobia

  • Orange Cream, Concentrate | The Clear | Colorado
  • Zen Pure Reserve Oil, Concentrate | Surterra | Florida
  • Purple Haze #44, Wax | Prime Wellness | Pennsylvania


Depression

  • Flo, Flower | Emerald Fields | Colorado
  • Zen Pure reserve Oil | Surterra | Florida
  • Florida Black Haze #14, Flower | Prime Wellness | Pennsylvania

PTSD

  • Flo, Flower | Emerald Fields | Colorado
  • Holy Roller Og, Flower | Bold | Arkansas
  • Terra Penn Wife’s Poison, Concentrate | Terrapin | Pennsylvania

Gostrointestinal Problems

  • Jillybean, Flower | Baseball 18 | Colorado
  • Lemon G, Flower | Terrapin | Pennsylvania
  • Harmony, Concentrate | Luxlyte | New York

Top Rated in Florida

Anxiety

  • Zen Pure Reserve Oil, Concentrate | Surterra
  • Ac/Dc, Concentrate | Trulieve
  • Super Sour Diesel, Concentrate | Trulieve

Insomnia

  • Granddaddy Purple, Concentrate | Curaleaf
  • 9lb Hammer, Concentrate | Trulieve
  • Vidacann Indica, Pill | Vidacann

Agoraphobia

  • Zen Pure Reserve Oil | Surterra
  • Ac/Dc, Concentrate | Trulieve
  • Suer Sour Diesel, Concentrate | Trulieve

Depression

  • Zen Pure Reserve Oil | Surterra
  • Ac/Dc, Concentrate | Trulieve
  • Super Sour Diesel, Concentrate | Trulieve

PTSD

  • Ac/Dc, Concentrate | Trulieve
  • Super Sour Diesel, Concentrate | Organic Smart Cart
  • Jack Herer, Concentrate | Curaleaf

Gastrointestinal Problems

  • Zen, Concentrate | Surterra
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  • Revive AM Blend, Concentrate | Surterra

DOWNLOAD RELEAF APP TODAY TO TRACK, LEARN FROM, AND IMPROVE YOUR USE OF CANNABIS BY VISITING: releaf.at/GRAM

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Scientists & Researchers

Dr. Salm Live Interview

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In case you missed the live video from our friends at Nugtopia, here it is! Jordan Person from Gram Magazine interviews Dr. Salm, a cannabis scientist that lived at an Antarctic Research station for 3 months! Covering terpenes, isolation and more…

Nugtopia 3 Pm

Jordan Person from Gram Magazine and Dr. Salm a cannabis scientist that lived at an Antarctic Research station for 2 years!

Posted by Tom Quigley on Monday, April 20, 2020

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Scientists & Researchers

Russo’s Research

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Dr. Russo comments in his latest editorial how the medical community has failed to appropriately manage chronic conditions such as pain and other debilitating diseases.

“The National Academies of Sciences, Engineering, and Medicine opined in 2017 that “there is conclusive or substantial evidence that cannabis or cannabinoids are effective: for the treatment of chronic pain in adults.”2

 Russo states that we need to face the facts:

– What doctors are currently using (opioids and non-opioids) is not effective in managing patients’ symptoms, and the lack of willingness tof many medical professionals to consider other options leaves the patients suffering.

– There is no longitudinal data that shows the efficacy of using opioids long term for chronic noncancer pain, and there is not much being developed in the drug market that aims to make any difference in how we currently treat patients.

 – Whether anyone likes it or not, increasingly millions of people around the globe are utilizing cannabis to treat their pain, and observational studies and surveys repeatedly demonstrate that pain is the top medical indication for cannabis usage, in the range of 70% of all patients.5

– No medication is deemed commercially successful unless the patient reports clinical improvements and perceives that they are improving due to the drug.

– There truly is no way to take an objective measurement of pain in the clinical field.

In order for anything in the medical/ biotechnology field to be taken seriously, there needs to be a randomized, double-blind placebo study with results that can be easily replicated and that is why cannabis has not been taken seriously for its therapeutic benefits. Due to the schedule 1 nature it makes it extremely difficult for researchers to do double-blind placebo studies. There is so much red tape on the subject that we are left with anecdotal evidence from patients along with the few clinical trials that are available using Sativex, the synthetic version of a 1:1 THC CBD oral mucosal spray.

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